human immune response – Communicable Diseases Research

Humanized mice for investigating SARS-CoV-2 lung infection and associated human immune responses

Article

Published on 2022-10-012022-11-15
Journal: European Journal of Immunology
[Category] COVID19(2023년), SARS, 치료기술,

Clinical implications of host genetic variation and susceptibility to severe or critical COVID-19

심각하거나 치명적인 COVID-19에 대한 숙주 유전자 변이 및 감수성의 임상적 의미

Review

Published on 2022-08-192022-09-11
Journal: Genome Medicine
[Category] SARS, 변종, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 advanced age age allergy Asymptomatic disease clinical clinical implications Clinical management clinical picture Comorbidities convergence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Critical deficiency develop Effects expected Factor Genetic genetic finding genetic screening Genetic variant Genetic variation healthy individual heterogeneous Host host genetics human immune response IFN-I Immunity implication indicate Infectious disease interferon Male sex malignancies manifestation Mendelian disorder Mendelian disorders modulate pandemic pathogenic variant pathway Pathways Patient Pneumonia predisposition Prevalence rare variant Rare variants risk factor SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe manifestations of COVID-19 shown susceptibility susceptibility loci the interferon TLR7 virus X-linked
[DOI] 10.1186/s13073-022-01100-3 PMC 바로가기 [Article Type] Review

Comparative analysis of human immune responses following SARS-CoV-2 vaccination with BNT162b2, mRNA-1273, or Ad26.COV2.S

Research

Published on 2022-07-062022-10-05
Journal: NPJ Vaccines
[Category] 유전자 메커니즘,

Helminth antigens differentially modulate the activation of CD4 + and CD8 + T lymphocytes of convalescent COVID-19 patients in vitro

기생충 항원은 시험관 내에서 회복기 COVID-19 환자의 CD4 + 및 CD8 + T 림프구의 활성화를 차등적으로 조절합니다

Article

Published on 2022-06-282022-09-11
Journal: BMC Medicine
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Activation activation markers. addition African age analyzed Antigen antigens Ascaris lumbricoides Brugia malayi caused CD137 CD137 (4-1BB) CD4 CD4+ CD4+ helper and CD8+ T cytotoxic T cells CD69 CD8 CD8+ cell culture supernatants cell-mediated immune response convalescent COVID-19 patient coronavirus coronavirus disease Coronavirus disease 2019 country Course COVID-19 COVID-19 patient COVID-19 patients cytokine expression Cytotoxic T cell Cytotoxic T cells death Disease progression Effect Endemic evade expression Factors flow cytometry Frequency genetics helminth Helminth antigens helper human immune response Hypothesis IFN-γ IFNγ IL-10 IL-6 immune immune reactivity immune responses in vitro incidence of COVID-19 investigated mechanisms moderate modulate MONITOR Mortality not affected offer Onchocerca volvulus pandemic parasites PBMC PBMCs peptides Prevalence reactivity reduced reduction remained Respiratory disease SARS-CoV-2 SARS-CoV-2 peptide SARS-CoV-2 peptides SARS-CoV-2 transmission significantly significantly increased Spread Stimulation sub-Saharan Africa Support suppress T cell T cell response T cells T helper cells T lymphocyte TNFα Vaccines virus was measured were used
[DOI] 10.1186/s12916-022-02441-x PMC 바로가기 [Article Type] Article

A humanized mouse model of chronic COVID-19

만성 COVID-19의 인간화 마우스 모델

Article

Published on 2022-06-012022-09-11
Journal: Nature biotechnology
[Category] Fulltext, MERS, 유전자 메커니즘, 임상, 진단, 치료기술, 치료법, 치료제,

[키워드] acute respiratory syndrome adaptive adeno-associated virus antibody coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 disease early infection feature fibrosis human ACE2 human immune response humanized immune response immune responses immunological immunopathology Infection Infectious disease Inflammatory inflammatory macrophage inflammatory macrophages Injury interferon interferon-stimulated gene lung Lung pathology Lungs lymphopenia Macrophage macrophages mechanism mice Patient respiratory Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe disease steroid Steroids sustained T cell T cell lymphopenia Viral Viral RNA weight loss
[DOI] 10.1038/s41587-021-01155-4 PMC 바로가기 [Article Type] Article

Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection

인간화 마우스는 SARS-CoV-2 감염 동안 인간 폐 조직 보호를 정의하는 대식세포가 풍부한 유전자 서명을 나타냅니다

Article

Published on 2022-04-192022-09-11
Journal: Cell Reports
[Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단,

[키워드] Antiviral antiviral responses cellular and molecular Clinical outcome composed COVID-19 CP: Immunology CP: Microbiology differentiation driven by fetal gene signature highlight histopathological Histopathology Human human immune response human immune responses to SARS-CoV-2 Human immune system human lung human lung tissue humanized humanized mice identify immune mechanism immune responses immunological mechanism immunology Infection knowledge lack lung Lung protection lung tissue Macrophage Macrophage infiltration Macrophage response macrophage responses macrophage responses to SARS-CoV-2 mice Microbiology mouse model Mouse models mouse models of SARS-CoV-2 pathway Phenotypes platform pulmonary immune responses. SARS-COV-2 infection severe inflammation signaling pathway tissue type I interferon upregulation
[DOI] 10.1016/j.celrep.2022.110714 PMC 바로가기 [Article Type] Article

Immunotherapy and CRISPR Cas Systems: Potential Cure of COVID-19?

면역 요법 및 CRISPR Cas 시스템: COVID-19의 잠재적 치료?

Review

Published on 2022-03-302022-09-11
Journal: Drug design, development and therapy
[Category] MERS, SARS, 변종, 진단,

[키워드] affected antibody CAR-T caused Cell cells circumvent clustered regularly interspaced short palindromic repeat condition convalescent plasma COVID-19 COVID-19 disease COVID-19 patient COVID-19 patients COVID-19 treatment CRISPR CRISPR Cas cure degrade Disease progression feasible human body human immune response hypothese hypotheses Immune cell immune cells immune response immune responses Immunity Immunotherapy immunotherapy. individual infected individuals Infection Mild natural infection Neutralizing antibodies neutralizing antibody NK cells overcome pandemic Potential Prevent problem progression question raise risk SARS-CoV-2 SARS-COV-2 infection Severe case Side effects specificity Stage T cells treat Treatment Vaccine variants of concern Viral Viral RNA
[DOI] 10.2147/DDDT.S347297 PMC 바로가기 [Article Type] Review

Regulation of gliotoxin biosynthesis and protection in Aspergillus species

아스 페르 길 루스 종에서의 글리 톡신 생합성 및 보호의 조절

Research Article

Published on 2022-01-182022-09-06
Journal: PLoS Genetics
[Category] Communicable Disease,

[키워드] Analysis approach aspergillosis Aspergillus Aspergillus fumigatus Aspergillus oryzae best cause colonisation component conserved disease Disease progression enzyme expresse expression expression of gene expression pattern facilitate fungal Genes genetic determinant genetic determinants Genome Glia homolog homologs human immune response identify Immune cell impair include involved kojic acid mechanism metabolism modulated mycotoxin negative regulation neutralising nidulan nidulans observé occur Occurrence pathogenicity producing regulate required responses RNA-sequencing screened secrete secretion sensitivity significantly sulfur Taking TFS toxic effect toxic effects transcription factor transcription factors transcriptional transcriptional response virulence
[DOI] 10.1371/journal.pgen.1009965 PMC 바로가기 [Article Type] Research Article

COVID-19 Mechanisms in the Human Body—What We Know So Far

인체의 COVID-19 메커니즘 - 우리가 지금까지 알고 있는 것

Review

Published on 2021-11-012022-09-11
Journal: Frontiers in Immunology
[Category] MERS, SARS, 변종,

[키워드] accumulated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addressed animal models being caused Cell Cell culture changed complications conducted consequence coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 dysregulations elapsed Evidence experiments extreme globe greater greater transmissibility Health Human human body human immune response Immune escape immune response immunological dysregulations Infection initial knowledge measure mechanism mechanisms molecular mechanism molecular mechanisms organ-specific organoids organotropism pandemic Pathogenesis pathogenic mechanisms physiological systems respiratory SARS-CoV-2 SARS-CoV-2 variants scenario Survivors systemic manifestations the disease therapeutic tissue tissue tropism type strain variant Viral virulence virus virus–host interactions wild-type strain
[DOI] 10.3389/fimmu.2021.693938 PMC 바로가기 [Article Type] Review

A Barcoded Flow Cytometric Assay to Explore the Antibody Responses Against SARS-CoV-2 Spike and Its Variants

SARS-CoV-2 스파이크 및 그 변이체에 대한 항체 반응을 조사하기 위한 바코드 유세포 분석 분석

Immunology

Published on 2021-09-232022-09-11
Journal: Frontiers in Immunology
[Category] SARS, 변종, 진단,

[키워드] accumulate Against Alpha Alpha variant B cell Beta Beta variant boost cell line characteristic chimeric color coronavirus COVID-19 COVID-19 patient COVID-19 patients E484K effort evaluate expressed expression Flow flow cytometric flow cytometry fusion protein generate Health Health crisis higher affinity human immune response human population humoral immune response Humoral immunity IgA class IgG IgG response Immune escape immune response less life-threatening lymphoma mutant Mutation N501Y Pneumonia Point mutation Protein protocol RBD receptor ACE2 receptor-binding domains reduce expression response S protein SARS-CoV-2 SARS-CoV-2 pandemic serum antibody severe disease manifestation spike Spike protein Spread spread to the patient the receptor-binding domain this new coronavirus vaccination variant variant of SARS-CoV-2 variants variants of SARS-CoV-2 Viral viral entry virus virus variants wild type WT S
[DOI] 10.3389/fimmu.2021.730766 PMC 바로가기 [Article Type] Immunology